Cutting Edge Cookie Chronicle

Spring 2022 brings with it this excellent paper in Analytical and Bioanalytical Chemistry from Leeds fellow, Fabio Marcuccio. In collaboration with medical researchers at the University of Newcastle upon Tyne.  Fabio used a nanobioscopy technology developed by Paolo Actis’ research group in 2014 to isolate cells from surrounding tissues.

Fabio’s study demonstrates for the first time that subcellular biopsy (an adapted version of nanobiopsy)  can isolate organelles from subcellular compartments within human tissue. The technique successfully acquired mitochondria from skeletal muscle fibres. Organelles play a vital role in our ongoing understanding of disease because the diversity of mitochondria, along with other organelles in a human cell, dictates cellular physiology and, in a number of debilitating diseases, cellular pathophysiology.

Amazing work, Fabio!